dc.contributor.author | Osorio, José Henry | spa |
dc.date.accessioned | 2021-02-23 16:03:24 | |
dc.date.accessioned | 2021-03-07T10:01:28Z | |
dc.date.available | 2021-02-23 16:03:24 | |
dc.date.available | 2021-03-07T10:01:28Z | |
dc.date.issued | 2021-02-23 | |
dc.identifier.issn | 1657-9550 | |
dc.identifier.uri | https://doi.org/10.17151/biosa.2015.14.1.5 | |
dc.identifier.uri | https://repositorio.ucaldas.edu.co/handle/ucaldas/16282 | |
dc.description.abstract | Introducción: Los estudios in vitro, que buscan intermediarios de la degradación mitocondrial de ácidos grasos, facilitan el diagnóstico de alteraciones hereditarias o adquiridas en esa ruta metabólica. Objetivo: Analizar la producción de metabolitos en fibroblastos de pacientes con deficiencia de acil-CoA deshidrogenasa de cadena muy larga (VLCAD) con afectación muscular, incubados con ácido oleico deuterado. Materiales y Métodos: Se incubaron fibroblastos de tres pacientes con deficiencia de acil-CoA deshidrogenasa de cadena muy larga (VLCAD) con cardiomiopatía y de 10 controles en presencia de ácido oleico deuterado. Resultados: Se encontró un perfil característico luego de la incubación de fibroblastos con esta deficiencia. Conclusión: Este sustrato podría ser usado para realizar diagnóstico in vitro de la deficiencia de VLCAD con afectación muscular. | spa |
dc.description.abstract | Introduction: In vitro studies for searching intermediates of mitochondrial fatty acid degradation, are a tool for diagnosis of hereditary or adquire alterations of the above mentioned metabolic pathway. Objective: To analize the metabolite production in fibroblasts from patientes with very long chain acylCoA deficiency and muscular involvement incubated with deuterated oleic acid. Materials and Methods: Fibroblasts of three patients with very long chain acyl-CoA deficiency and cardiomyopathy and ten control were incubated with deuterated oleic acid. Results: It was found a characteristic profile after incubation of fibroblats with this deficiency. Conclusion: This substrate could be used to perform in vitro diagnosis of VLCAD deficiency with musclar involvement. | eng |
dc.format.mimetype | application/pdf | spa |
dc.format.mimetype | | spa |
dc.language.iso | spa | spa |
dc.publisher | Universidad de Caldas | spa |
dc.rights | Derechos de autor 2015 Biosalud | spa |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | spa |
dc.source | https://revistasojs.ucaldas.edu.co/index.php/biosalud/article/view/3803 | spa |
dc.subject | fatty acids | eng |
dc.subject | metabolism | eng |
dc.subject | mitochondrial β-oxidación | eng |
dc.subject | ácidos grasos | spa |
dc.subject | metabolismo | spa |
dc.subject | β-oxidación mitocondrial | spa |
dc.title | Estudio In vitro de la deficiencia de Acil-CoA deshidrogenasa de cadena muy larga con afectación muscular | spa |
dc.type | Artículo de revista | spa |
dc.type | Sección Artículos Originales | spa |
dc.type | Journal Article | eng |
dc.identifier.doi | 10.17151/biosa.2015.14.1.5 | |
dc.identifier.eissn | 2462-960X | |
dc.relation.citationendpage | 50 | |
dc.relation.citationissue | 1 | spa |
dc.relation.citationstartpage | 44 | |
dc.relation.citationvolume | 14 | spa |
dc.relation.ispartofjournal | Biosalud | spa |
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dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.title.translated | In vitro study of very long chain acyl-coa dehydrogenase deficiency with muscular involvement | eng |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | spa |
dc.type.content | Text | spa |
dc.type.driver | info:eu-repo/semantics/article | spa |
dc.type.redcol | http://purl.org/redcol/resource_type/ART | spa |
dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
dc.relation.citationedition | Núm. 1 , Año 2015 : Enero - Junio | spa |
dc.relation.bitstream | https://revistasojs.ucaldas.edu.co/index.php/biosalud/article/download/3803/3513 | |
dc.relation.bitstream | https://revistasojs.ucaldas.edu.co/index.php/biosalud/article/download/3803/3514 | |
dc.type.coarversion | http://purl.org/coar/version/c_970fb48d4fbd8a85 | spa |
dc.rights.coar | http://purl.org/coar/access_right/c_abf2 | spa |