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Propiedades eléctricas pasivas, de tejido de colon distal y recto porcino (Sus scrofa domesticus) ex vivo, basadas en la espectroscopia de bioimpedancia eléctrica (EBIE)

dc.contributor.advisorGonzalez-Correa, Carlos-Augusto
dc.contributor.advisorJaimes Morales, Samuel Alberto
dc.contributor.authorAguirre Cardona , Victoria Eugenia
dc.date.accessioned2023-07-04T14:05:43Z
dc.date.available2023-07-04T14:05:43Z
dc.date.issued2023-07-04
dc.identifier.urihttps://repositorio.ucaldas.edu.co/handle/ucaldas/19525
dc.descriptionIlustraciones, gráficasspa
dc.description.abstractspa:Se llevó a cabo el estudio de las propiedades eléctricas pasivas de tejido de colon distal y recto porcino, mediante la medición de la Espectroscopia de Bioimpedancia Eléctrica EBIE, haciendo uso tanto de la parte real como de la imaginaria de los espectros de resistividad eléctrica compleja. A partir de allí, se realizó un análisis estadístico y un modelado matemático mediante el método geométrico propuesto por González Correa (C. A. Gonzalez-Correa, 2019; González-Correa et al., 2022) y mediante el modelo de Cole, con el objetivo de determinar el comportamiento eléctrico del tejido a distintas distancias desde el esfínter anal. La importancia de este estudio es la de aportar información relevante de estas propiedades, para futuras aplicaciones relacionadas con el desarrollo de herramientas para la detección de enfermedades del colon en humanos, teniendo en cuenta la escasa literatura disponible en la actualidad y a que el colon y recto porcino son un modelo válido para su contraparte humano.spa
dc.description.abstracteng:It was carried out the study of the passive electrical properties of porcine distal colon and rectum by the Electrical Bioimpedance Spectroscopy EBIS measurements considering the real and imaginary part of the electrical resistivity spectrum. Then, statistical analysis and mathematical modelling with a geometrical proposed by González Correa (C. A. Gonzalez-Correa, 2019; González-Correa et al., 2022) and Cole model were made, in order to establish the electrical behavior of the tissue for different distances from the anal sphincter. The significance of this study is to bring relevant information about these properties for further developments in colorectal disease detection in humans, consider that the literature is scarce, and the porcine colorectal tissue is a valid model.eng
dc.description.tableofcontentsAgradecimientos / Resumen ejecutivo / Executive summary / Introducción / Capítulo 1. Presentación general / 1.1. Contextualización y justificación / 1.2. Planteamiento del problema / 1.3. Hipótesis de trabajo / 1.4. Objetivos / 1.4.1. Objetivo general / 1.4.2. Objetivos específicos / Capítulo 2. Marco conceptual / 2.1. Aspectos biológicos / 2.1.1. Colon distal y recto de cerdo y humano / 2.1.2. Estructura macroscópica del colon distal y recto de cerdo y humano / 2.1.3. Estructura microscópica del colon distal y recto de cerdo y humano / 2.1.4. Ultraestructura / 2.1.5. Perspectivas a futuro de la investigación / 2.2. Aspectos físicos / 2.2.1. Electricidad y Bioelectricidad / 2.2.2. Bioelectricidad / 2.2.3. Bioimpedancia eléctrica / 2.2.3.1. Espectroscopia de bioimpedancia eléctrica y zonas de dispersión / 2.2.3.2. Modelos de la bioimpedancia eléctrica / Capítulo 3. Marco metodológico/ 3.1. Desarrollo del protocolo de medición / 3.1.1 Metodología de desarrollo. / 3.1.1.1 Primer espécimen de prueba / 3.1.1.2 Segundo espécimen de prueba / 3.1.1.3 Tercer espécimen de prueba / 3.1.2. Protocolo para la recolección del espécimen y la toma de datos. / 3.2. Metodología para la medición de tejido colorrectal de cerdo ex vivo.... 45 3.3. Calibración de la sonda de medición / 3.3.1. Preparación y medición de las soluciones / 3.3.1.1. Calibración de la magnitud de la impedancia / 3.3.1.2. Calibración de la fase. / 3.3.1.3. Cálculo de la parte real y la parte imaginaria de la resistividad eléctrica. / 3.4. Estrategia para el ajuste de datos al modelo de Cole de dos dispersiones / 3.5. Descripción del planteamiento del análisis estadístico / 3.5.1. Igualdad entre lecturas / 3.5.2. Igualdad entre puntos / 3.5.3. Igualdad entre distancias / Capítulo 4. Resultados y análisis / 4.1. Calibración de la sonda / 4.1.1. Preparación y medición de soluciones / 4.1.2. Calibración de la Magnitud de la impedancia eléctrica / 4.1.3. Calibración de la fase de la impedancia eléctrica / 10 4.2. Análisis de tejido rectal y colon / 4.2.1. Comparación respecto a lecturas / 4.2.2. Comparación respecto a puntos / 4.2.3. Comparación respecto a distancia / 4.2.3.1. Diferencias en la parte real e imaginaria. / 4.2.4. Promedio por distancia / Capítulo 5. Discusión General / 5.1. Protocolo de medición / 5.2. Calibración de la sonda de medición y conversión a resistividad eléctrica / 5.3. Análisis de tejido colorrectal / 5.4. Hipótesis sobre la estructura de capas / Capítulo 6. Conclusiones y recomendaciones generales / 6.1. Conclusiones / 6.2. Recomendaciones / Referencias / Anexos / Apéndicespa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.language.isospaspa
dc.titlePropiedades eléctricas pasivas, de tejido de colon distal y recto porcino (Sus scrofa domesticus) ex vivo, basadas en la espectroscopia de bioimpedancia eléctrica (EBIE)eng
dc.typeTrabajo de grado - Maestríaspa
dc.contributor.researchgroupBioimpedancia eléctrica (Categoría A)spa
dc.description.degreelevelMaestríaspa
dc.identifier.instnameUniversidad de Caldasspa
dc.identifier.reponameRepositorio Institucional Universidad de Caldasspa
dc.identifier.repourlhttps://repositorio.ucaldas.edu.co/spa
dc.publisher.facultyFacultad de Ciencias para la Saludspa
dc.publisher.placeManizalesspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.subject.proposalBioimpedancia eléctricaspa
dc.subject.proposalPorcinospa
dc.subject.proposalColonspa
dc.subject.proposalRectospa
dc.subject.proposalElectrical bioimpedanceeng
dc.subject.proposalPorcineeng
dc.subject.proposalColoneng
dc.subject.proposalRectumeng
dc.subject.unescoCiencias médicas
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
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dc.description.degreenameMagister en Ciencias Biomédicasspa
dc.publisher.programMaestría en Ciencias Biomédicasspa
dc.description.researchgroupDetección precoz de cáncer mediante EBI, especialmente colorrectal, cutáneo y de cérvixspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa


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