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Eficacia clínica y radiológica del tratamiento con células mesenquimatosas intraarticulares para pacientes adultos con osteoartritis de rodilla reportada entre 2016 y 2021: Revisión sistemática de la literatura

dc.contributor.advisorSanchez Palacio, Natalia
dc.contributor.authorCabarcas, William Fernando
dc.contributor.authorMoreno Babilonia, Cesar Andres
dc.date.accessioned2022-04-25T23:46:02Z
dc.date.available2022-04-25T23:46:02Z
dc.date.issued2022-04-25
dc.identifier.urihttps://repositorio.ucaldas.edu.co/handle/ucaldas/17574
dc.descriptionIlustracionesspa
dc.description.abstractspa:Introducción: La Osteoartritis es una enfermedad crónica, progresiva, prevalente, con un alto impacto en los sistemas de salud y en la calidad de vida de los pacientes y familiares. El dolor y la limitación funcional son los síntomas más comunes, por lo que se han propuesto diferentes alternativas novedosas en su tratamiento, derivadas del uso de células mesenquimatosas intraarticulares que ayudan a reducir el impacto en su patogenia. Objetivo general: Evaluar la calidad de la evidencia sobre la eficacia clínica y radiológica del uso de las células mesenquimatosas intraarticulares en comparación con otros tratamientos intraarticulares (placebo, corticoesteroides y ácido hialurónico intraarticular) contra la osteoartritis de rodilla de cualquier etiología para pacientes adultos, reportada entre 2016 y 2021. Materiales y métodos: Se realizó una revisión sistemática en las bases de datos Science Direct, Scielo, Clinical Trials, Web of Science, OVID, SCOPUS, PubMed (Medline), Cochrane, Biblioteca Virtual en salud, Google Scholar de artículos publicados en inglés y español, entre el 1 de enero de 2016 y el 22 de agosto de 2021. Estudios que han evaluado la eficacia clínica y radiológica de las células mesenquimatosas intraarticulares en comparación con otros tratamientos intraarticulares (placebo, corticoesteroides y ácido hialurónico intraarticulares) contra la osteoartritis de rodilla. Resultados: Se obtuvieron veintidós ensayos clínicos entre estudios aleatorizados y no aleatorizados; para el análisis final con un número total de pacientes inyectados con las células madre que oscilaron entre 6 y 57. Un total de 422 pacientes fueron tratados con una variedad de células madre mesenquimales, y un total de 246 de los pacientes sirvieron como controles. En todos los estudios se incluyeron pacientes con índice de masa corporal por debajo de 35 kg/m2 y con artrosis Kellgren – Lawrence que oscilaba entre grado I a IV. Conclusiones: A pesar de la mejoría demostrada en la función articular y dolor con la aplicación de MSC intraarticular en un seguimiento a corto plazo y con marco muestral reducido, por el alto riesgo de sesgo de los artículos publicados actualmente y su baja calidad metodológica, antes de recomendar este tratamiento en la práctica clínica cotidiana se debe evaluar su eficacia y seguridad de manera más rigurosa.spa
dc.description.abstracteng:Introduction: Osteoarthritis is a chronic, progressive, prevalent disease, with a high impact on health systems and on the quality of life of patients and families. Pain and functional limitation are the most common symptoms, so different novel alternatives have been proposed in its treatment, derived from the use of intra-articular mesenchymal cells that help reduce the impact on its pathogenesis. Objective: To evaluate the quality of the evidence on the clinical and radiological efficacy of the use of intra-articular mesenchymal cells in comparison with other intra-articular treatments (placebo, corticosteroids and intra-articular hyaluronic acid) against knee osteoarthritis of any etiology for adult patients, reported between 2016 and 2021. Materials and methods: A systematic review was carried out in the databases Science Direct, Scielo, Clinical Trials, Web of Science, OVID, SCOPUS, PubMed (Medline), Cochrane, Virtual Health Library, Google Scholar of articles published in English and Spanish, between January 1, 2016 and August 22, 2021. Studies that have evaluated the clinical and radiological efficacy of intra-articular mesenchymal cells in comparison with other intra-articular treatments (placebo, intra-articular corticosteroids and hyaluronic acid) against osteoarthritis of the knee. Results: Twenty-two clinical trials were obtained between randomized and nonrandomized studies; for the final analysis with a total number of patients injected with the stem cells ranging from 6 to 57. A total of 422 patients were treated with a variety of mesenchymal stem cells, and a total of 246 of the patients served as controls. All studies included patients with a body mass index below 35 kg/m2 and KellgrenLawrence osteoarthritis ranging from grade I to IV. Conclusions: Despite the demonstrated improvement in joint function and pain with the application of intra-articular MSC in a short-term follow-up and with a reducedeng
dc.description.tableofcontents1. PLANTEAMIENTO DEL PROBLEMA Y JUSTIFICACIÓN / 2. MARCO TEÓRICO / 2.1. DEFINICIÓN DE LA OSTEOARTRITIS / 2.2. EPIDEMIOLOGÍA DE LA OSTEOARTRITIS / 2.3. PATOGENIA DE LA OSTEOARTRITIS / 2.3.1. Factores de riesgo / 2.4. CLASIFICACIÓN DE LA OSTEOARTRITIS / 2.5. DIAGNÓSTICO DE LA OSTEOARTRITIS / 2.6. TRATAMIENTO DE LA OSTEOARTRITIS / 2.7. DEFINICIÓN DE CÉLULAS MADRE MESENQUIMALES / 2.8. MECANISMO DE ACCIÓN DE LA MSC EN LA OSTEOARTRITIS / 3. OBJETIVOS / 3.1. OBJETIVO GENERAL / 3.2. OBJETIVOS ESPECÍFICOS / 4. METODOLOGÍA / 4.1. TIPO DE ESTUDIO / 4.2. PREGUNTA PICO / 4.3. ESTRATEGIA DE BÚSQUEDA / 4.4. CRITERIOS DE INCLUSIÓN / 4.5. CRITERIOS DE EXCLUSIÓN / 4.6. EVALUACIÓN DE LA CALIDAD Y DEL RIESGO DE SESGOS / 4.7. SÍNTESIS DE LOS DATOS / 5. CONSIDERACIONES ÉTICAS / 6. RESULTADOS / 6.1. CARACTERÍSTICAS DE LOS ESTUDIOS / 6.2. EVALUACIÓN DEL RIESGO DE SESGO / 6.3. EVALUACIÓN DE LA CALIDAD DE LA EVIDENCIA / 6.4. EFICACIA DE LAS CÉLULAS MESENQUIMALES EN LA OSTEOARTRITIS / 6.4.1. Células Estromales Mesenquimales Derivadas De Tejido Adiposo / 6.4.2. Células Estromales Mesenquimales Derivadas De Médula Ósea / 6.4.3. Fracción Vascular Estromal, Células Derivadas Del Cordón Umbilical y La Placenta / 6.5. EVENTOS ADVERSOS / 7. DISCUSIÓN / 8. CONCLUSIONES / 9. ANEXOS / ANEXO 1. ESTRATEGIAS DE BÚSQUEDA / 10. REFERENCIAS BIBLIOGRÁFICASspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.language.isospaspa
dc.titleEficacia clínica y radiológica del tratamiento con células mesenquimatosas intraarticulares para pacientes adultos con osteoartritis de rodilla reportada entre 2016 y 2021: Revisión sistemática de la literaturaspa
dc.typeTrabajo de grado - Especializaciónspa
dc.description.degreelevelEspecializaciónspa
dc.identifier.instnameUniversidad de Caldasspa
dc.identifier.reponameRepositorio Institucional Universidad de Caldasspa
dc.identifier.repourlhttps://repositorio.ucaldas.edu.co/spa
dc.publisher.facultyFacultad de Ciencias para la Saludspa
dc.publisher.placeManizalesspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.subject.proposalOsteoartritis de rodillaspa
dc.subject.proposalCélulas madre mesenquimatosasspa
dc.subject.proposalInyección intraarticularspa
dc.subject.unescoCiencias médicas
dc.subject.unescoEpidemiología
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dc.description.degreenameEspecialista en Epidemiologíaspa
dc.publisher.programEspecialización en Epidemiologíaspa
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