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Expresión inmunohistoquimica de subpoblaciones linfocitarias en la regresión tumoral, de pacientes sometidos a quimioterapia como tratamiento del tumor venéreo transmisible canino
| dc.contributor.advisor | Pedraza-Ordoñez, Francisco | |
| dc.contributor.author | Ramírez Ante, Juan Carlos | |
| dc.date.accessioned | 2021-12-07T14:57:01Z | |
| dc.date.available | 2021-12-07T14:57:01Z | |
| dc.date.issued | 2021-12-07 | |
| dc.identifier.uri | https://repositorio.ucaldas.edu.co/handle/ucaldas/17233 | |
| dc.description | Ilustraciones, gráficas | spa |
| dc.description.abstract | spa:cumento. Repetible para TODOS los idiomas (Colocar prefijo), Ejemplo spa: El tumor venéreo transmisible canino es uno de los tres canceres transmisibles observados en mamíferos, siendo un cáncer contagioso que se transmite naturalmente entre perros mediante una trasferencia alogénica de células neoplásicas vivas principalmente en el momento del coito. Se ha estimado que este tumor trasmisible surgió hace 11.000 años y a partir de ese momento empezó su viaje a colonizar el mundo, hasta el día de hoy mostrando una distribución mundial sustentada en reportes de caso en los cinco continentes. Estas células al momento de implantarse pueden evitar la respuesta inmune del hospedero escapándose de la barrera del complejo mayor de histocompatibilidad. Mostrando una actividad inmunológica diferente en sus fases de progresión y regresión. El objetivo de este estudio fue evaluar la expresión inmunohistoquímica de subpoblaciones linfocitarias en la regresión tumoral de pacientes sometidos a quimioterapia como tratamiento del tumor venéreo transmisible canino, la relación que pueda existir con la respuesta al tratamiento y la fase histopatológica en que se encuentre antes y durante la tercera semana de tratamiento. Para el presente estudio se utilizaron fragmentos de TVTC 24 caninos antes de iniciar quimioterapia con sulfato de Vincristina, igualmente se tomaron 15 fragmentos durante la tercera semana posterior inicio de tratamiento antes de la aplicación de la cuarta sesión de quimioterapia. Se realizó inmunohistoquímica para la expresión de anticuerpos CD3, CD8 y CD79 de las muestras de TVTC obtenidas. CD3 y CD8 mostraron aumento en la expresión en comparación con CD79, principalmente en los pacientes que requirieron un número más elevado de sesiones de quimioterapia, además, se observó mayor expresión de CD8 en las muestras en la fase de regresión y disminución significativa en la marcación de CD3 y CD8 durante el tratamiento sugiriendo que el uso de sulfato de vincristina puede afectar la respuesta inmunológica intratumoral del TVTC. Desde su primer reporte hace cerca de 140 años el TVTC ha despertado el interés de científicos convirtiéndolo en un modelo de estudio de comportamiento, desarrollo, inmunología y origen del cáncer en animales. | spa |
| dc.description.abstract | eng:Canine transmissible venereal tumor is one of the three transmissible cancers observed in mammals, being a contagious cancer that is transmitted naturally between dogs by allogeneic cell transfer neoplastic cells living mainly at the time of intercourse. It has been estimated that this Transmissible tumor arose 11,000 years ago and from that moment began its voyage to colonize the world, to this day showing a worldwide distribution supported by case reports in the five continents. These cells at the moment implanted, they can avoid the host's immune response by escaping from the major histocompatibility complex barrier. Displaying an activity different immunology in its phases of progression and regression. The goal of this study was to evaluate the immunohistochemical expression of lymphocyte subpopulations in tumor regression of patients undergoing chemotherapy as treatment of the canine transmissible venereal tumor, the relationship that may exist with the response treatment and histopathological phase before and during the third week of treatment. For the present study, fragments of 24 canine TVTC before starting chemotherapy with Vincristine sulfate, Likewise, 15 fragments were taken during the third week after the start of treatment before the application of the fourth chemotherapy session. It has been made immunohistochemistry for the expression of CD3, CD8 and CD79 antibodies from TVTC samples obtained. CD3 and CD8 showed increased expression in compared with CD79, mainly in patients who required a number of higher number of chemotherapy sessions, in addition, greater expression was observed of CD8 in the samples in the regression phase and significant decrease in the CD3 and CD8 labeling during treatment suggesting that the use of sulfate Vincristine may affect the intratumoral immune response to TVTC. From its first report about 140 years ago the TVTC has aroused the interest of scientists turning it into a model of study of behavior, development, immunology and origin of cancer in animals. | eng |
| dc.description.tableofcontents | Resumen/1. Introducción/ 2. Planteamiento del problema/ 3. Justificación/ 4. Marco teórico/ 4.1Tumor venéreo trasmisible canino/ 4.2TVTC y la búsqueda de su origen/ 4.3Distribución del TVTC/ 4.4Diagnóstico del TVTC / 4.4.1 Citología/ 4.4.2 Histopatología/ 4.4.3 Reacción en Cadena de Polimerasa (PCR)/4.5 Inmunohistoquímica/ 4.6 Tratamiento/ 4.7 Respuesta inmune contra el TVTC/ 5. OBJETIVOS/ 5.1Objetivo General/ 5.2Objetivos Específicos/ 6. MATERIALES Y METODOS/ 6.1Comité de Ética/ 6.2Procedimientos y Manejo de Animales/ 6.3Diagnostico TVTC/ 6.4Colecta y procesamiento de muestras/ 6.5Análisis histopatológico/ 6.6Análisis Molecular / 6.6.1 Extracción de ADN/ 6.6.2 PCR en tiempo real cuantitativa (qPCR)/6.7Inmunohistoquímica CD3, CD8 y CD79/ 6.7.1 Validación de la marcación/ 6.8Análisis estadístico/ 7. RESULTADOS/ 7.1 Datos epidemiológicos, clínicos y respuesta al tratamiento/ 7.2 Examen citológico/ 7.3 Respuesta al tratamiento/ 7.4 Clasificación histopatológica/ 4 7.5 Análisis molecular qPCR/ 7.5.1 Detección LINE-1/c-myc/ 7.5.2 Detección CDKN2A/ 7.6 Expresión Inmunohistoquímica/ 7.6.1 Marcación porcentual CD3, CD8 y CD79/ 8. DISCUSIÓN/ 9. CONCLUSIONES/ 10.REFERENCIAS/ 11.ANEXOS. | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.language.iso | eng | spa |
| dc.language.iso | spa | spa |
| dc.title | Expresión inmunohistoquimica de subpoblaciones linfocitarias en la regresión tumoral, de pacientes sometidos a quimioterapia como tratamiento del tumor venéreo transmisible canino | spa |
| dc.type | Trabajo de grado - Maestría | spa |
| dc.contributor.researchgroup | Patología Veterinaria (Categoría A) | spa |
| dc.description.degreelevel | Maestría | spa |
| dc.identifier.instname | Universidad de Caldas | spa |
| dc.identifier.reponame | Repositorio institucional Universidad de Caldas | spa |
| dc.identifier.repourl | https://repositorio.ucaldas.edu.co/ | spa |
| dc.publisher.faculty | Facultad de Ciencias Agropecuarias | spa |
| dc.publisher.place | Manizales | spa |
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| dc.rights.accessrights | info:eu-repo/semantics/closedAccess | spa |
| dc.rights.accessrights | info:eu-repo/semantics/closedAccess | spa |
| dc.rights.accessrights | info:eu-repo/semantics/closedAccess | spa |
| dc.rights.accessrights | info:eu-repo/semantics/closedAccess | spa |
| dc.subject.lemb | Perros | |
| dc.subject.lemb | Tumores | |
| dc.subject.proposal | Cáncer transmisible | spa |
| dc.subject.proposal | Complejo mayor de histocompatibilidad | spa |
| dc.subject.proposal | Reordenamiento genómico | spa |
| dc.subject.proposal | Neoplasia | spa |
| dc.subject.proposal | Quimioterapia | spa |
| dc.subject.proposal | Aleogénico | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_bdcc | spa |
| dc.type.content | Text | spa |
| dc.type.driver | info:eu-repo/semantics/masterThesis | spa |
| dc.type.redcol | https://purl.org/redcol/resource_type/TM | spa |
| dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
| oaire.version | http://purl.org/coar/version/c_ab4af688f83e57aa | spa |
| oaire.accessrights | http://purl.org/coar/access_right/c_14cb | spa |
| dc.description.degreename | Magister en Ciencias Veterinarias | spa |
| dc.publisher.program | Maestría en Ciencias Veterinarias | spa |
| dc.rights.coar | http://purl.org/coar/access_right/c_14cb | spa |
