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Factores clínicos y genéticos asociados a eventos cardiovasculares en pacientes con diabetes tipo 2
dc.contributor.advisor | Castano Molina, Carlos Eduardo | |
dc.contributor.author | Giraldo Gonzalez, German Camilo | |
dc.date.accessioned | 2024-06-05T20:44:58Z | |
dc.date.available | 2024-06-05T20:44:58Z | |
dc.date.issued | 2024-06-05 | |
dc.identifier.uri | https://repositorio.ucaldas.edu.co/handle/ucaldas/19927 | |
dc.description | Ilustraciones | spa |
dc.description.abstract | No existen datos respecto al perfil genético de riesgo cardiovascular en pacientes con diabetes mellitus tipo 2 (DMT2) y enfermedad cardiovascular, en población colombiana. Estos pacientes representan una alta recurrencia de enfermedad cardiovascular y suelen requerir más intervenciones. Métodos y resultados: se realizó un estudio de epidemiología genética transversal en el que se analizaron 11 alelos de riesgo para eventos cardiovasculares y se buscó asociación con la complejidad de la enfermedad coronaria y los factores de riesgo clínicos y metabólicos. Se documentó una alta prevalencia de homocigosis de los alelos, teniendo el 99% de los pacientes al menos. Cada alelo por aparte no logró ser diferenciador y en los alelos de riesgo más frecuentes agrupados,tampoco lograron significancia estadística. Sin embargo; por eliminación acorde a asociaciones de GWAS para enfermedad coronaria, se encontraron 5 alelos con un OR de 5,2 p 0.007 para enfermedad coronaria más compleja. Al comparar por edad, sexo, factores de riesgo tradicionales, historia familiar, factores metabólicos, no se encontraron diferencias estadísticamente significativas. Conclusión: un grupo de 5 alelos presente en pacientes con DMT2 y enfermedad cardiovascular es potencialmente evaluable en estudios prospectivos o de casos y controles para establecer su capacidad de predicción del riesgo cardiovascular. | spa |
dc.description.abstract | There are no data regarding the genetic profile of cardiovascular risk in patients with diabetes mellitus type 2 (T2DM) and cardiovascular disease in the Colombian population. These patients represent a high recurrence of cardiovascular disease and usually require more interventions. Methods and results: a cross-sectional genetic epidemiology study was carried out in which 11 risk alleles for cardiovascular events were analyzed and an association was sought with the complexity of coronary heart disease and clinical and metabolic risk factors. A high prevalence of homozygosity of the alleles was documented, with 99% of patients having at least 3. Each allele separately failed to be differentiating. The most frequent risk alleles grouped together also did not achieve statistical significance. However, by elimination according to GWAS associations for coronary heart disease, 5 alleles were found with an OR of 5.2 p 0.007 for more complex coronary heart disease. When comparing by age, sex, traditional risk factors, family history, and metabolic factors, no statistically significant differences were found. Conclusion: a group of 5 alleles present in patients with T2DM and cardiovascular disease is potentially evaluated in prospective orcase-control studies to establish its ability to predict cardiovascular risk | eng |
dc.description.tableofcontents | INTRODUCCIÓN / 1. PLANTEAMIENTO DEL PROBLEMA Y ANTECEDENTES / 1.1 El riesgo cardiovascular / 1.2 Factores de riesgo / 1.3 Pregunta de investigación / 2. JUSTIFICACIÓN / 3. REFERENTE TEÓRICO / 3.1 Diabetes tipo 2 / 3.1.1 Fisiopatología de la diabetes tipo 2 / 3.1.2 Diagnóstico / 3.1.3 Cuadro clínico / 3.1.4 Tratamiento / 3.1.5 Complicaciones / 3.2 Enfermedad cardiovascular / 3.2.1 Evaluación del riesgo cardiovascular del paciente con diabetes tipo 2 / 3.2.1Tratamiento / 3.2.2 Objetivos terapéuticos / 3.3 Genética / 4. OBJETIVOS / 4.1 Objetivo general / 4.2 Objetivos específicos / 5. METODOLOGÍA / 5.1 Tipo de estudio / 5.2 Población / 5.2.1 Muestra / 5.2.2 Criterios de inclusión / 5.2.3 Criterios de exclusión / 5.3 Variables / 5.4 Plan de análisis de la información / 6. CONSIDERACIONES ÉTICAS / 7. RESULTADOS / 8. DISCUSIÓN / 9. CONCLUSIONES Y RECOMENDACIONES / 9.1 Conclusiones / 9.2 Recomendaciones / REFERENCIAS BIBLIOGRÁFICAS / | spa |
dc.format.mimetype | application/pdf | spa |
dc.language.iso | eng | spa |
dc.language.iso | spa | spa |
dc.title | Factores clínicos y genéticos asociados a eventos cardiovasculares en pacientes con diabetes tipo 2 | spa |
dc.type | Trabajo de grado - Doctorado | spa |
dc.contributor.researchgroup | Promoción de la Salud y Prevención de la Enfermedad (Categoría A) | spa |
dc.description.degreelevel | Doctorado | spa |
dc.identifier.instname | Universidad de Caldas | spa |
dc.identifier.reponame | Repositorio Institucional Universidad de Caldas | spa |
dc.identifier.repourl | https://repositorio.ucaldas.edu.co/ | spa |
dc.publisher.faculty | Facultad de Ciencias para la Salud | spa |
dc.publisher.place | Manizales | spa |
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dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.subject.proposal | Type 2 diabetes mellitus cardiovascular disease genetics coronary heart disease | eng |
dc.subject.proposal | Enfermedad cardiovascular | spa |
dc.subject.proposal | Genética | spa |
dc.subject.proposal | Enfermedad coronaria | spa |
dc.subject.proposal | Diabetes tipo 2 | spa |
dc.subject.proposal | Type 2 diabetes | eng |
dc.subject.proposal | Mellitus cardiovascular | eng |
dc.subject.proposal | Disease genetics | eng |
dc.subject.proposal | Coronary heart disease | eng |
dc.subject.unesco | Ciencias médicas | |
dc.type.coar | http://purl.org/coar/resource_type/c_db06 | spa |
dc.type.content | Text | spa |
dc.type.driver | info:eu-repo/semantics/doctoralThesis | spa |
dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
oaire.version | http://purl.org/coar/version/c_ab4af688f83e57aa | spa |
oaire.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |
dc.description.degreename | Doctor(a) en Ciencias de la Salud | spa |
dc.publisher.program | Doctorado en Ciencias de la Salud | spa |
dc.description.researchgroup | clinica | spa |
dc.rights.coar | http://purl.org/coar/access_right/c_abf2 | spa |